Michael C. Hewitt
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Multiple Myeloma Research and Treatments, Carbohydrate Chemistry and Synthesis, Trypanosoma species research and implications, Neuroscience and Neuropharmacology Research
Most-Cited Works
- → Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria(2002)485 cited
- → BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain(2012)375 cited
- → Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials(2016)214 cited
- → Rapid Synthesis of a Glycosylphosphatidylinositol-Based Malaria Vaccine Using Automated Solid-Phase Oligosaccharide Synthesis(2002)134 cited
- → Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains(2016)118 cited
- → Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)(2016)111 cited
- → Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors(2013)103 cited
- → “Cap-Tag”—Novel Methods for the Rapid Purification of Oligosaccharides Prepared by Automated Solid-Phase Synthesis Financial support from the donors of the Petroleum Research Fund, administered by the ACS (ACS-PRF 34649-G1), Merck (Predoctoral Fellowship for E.R.P.), Boehringer-Ingelheim (Predoctoral Fellowship for E.R.P.), and the NIH (Biotechnology Training Grant for M.C.H.) is gratefully acknowledged. Funding for the MIT-DCIF Inova 501 was provided by the NSF (Award CHE-9808061). Funding for the MIT-DCIF Avance (DPX) 400 was provided by the NIH (Award 1S10RR13886-01). We thank Silicycle (Quebec City, Canada) for the generous gift of fluorous silica gel and isocyanate silica gel scavenger resin. We thank Dr. O. Plante for helpful discussions and help with the automated oligosaccharide synthesizer.(2001)88 cited
- → The kinetic isotope effect in the search for deuterated drugs(2010)80 cited
- → Solution and Solid-Support Synthesis of a Potential Leishmaniasis Carbohydrate Vaccine(2001)79 cited