The First Total Synthesis of Dragmacidin D
Journal of the American Chemical Society2002Vol. 124(44), pp. 13179–13184
Citations Over TimeTop 10% of 2002 papers
Abstract
The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine- and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to the completion of the natural product.
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