Total Synthesis of the Chlorinated Marine Natural Product Dysamide B
Organic Letters2006Vol. 8(23), pp. 5401–5404
Citations Over TimeTop 14% of 2006 papers
Abstract
[Structure: see text] Two approaches to the synthesis of (2S,4S)-5,5-dichloroleucine are compared, and the parent amino acid was used in the first total synthesis of the polychlorinated marine natural product, dysamide B. A key step was the lead tetraacetate-mediated decarboxylation of an alpha,alpha-dichloro acid in the presence of 1,4-cyclohexadiene to generate the dichloromethyl group.
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