Structure-Based Design of Estrogen Receptor-β Selective Ligands
Journal of the American Chemical Society2004Vol. 126(46), pp. 15106–15119
Citations Over TimeTop 10% of 2004 papers
Eric S. Manas, Rayomand J. Unwalla, Zhang B. Xu, Michael S. Malamas, Chris P. Miller, Heather A. Harris, Chu-Lai Hsiao, Tatos Akopian, Wah-Tung Hum, Karl Malakian, Scott Wolfrom, Ashok R. Bapat, Ramesh A. Bhat, Mark Stahl, W.S. Somers, Juan Carlos Álvarez
Abstract
We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal structures of these ligands complexed to both ERalpha and ERbeta are described. We also discuss how molecular modeling was used to take advantage of subtle differences between the two binding cavities in order to optimize selectivity for ERbeta over ERalpha. Quantum chemical calculations are utilized to gain insight into the mechanism of selectivity enhancement. Despite only two relatively conservative residue substitutions in the ligand binding pocket, the most selective compounds have greater than 100-fold selectivity for ERbeta relative to ERalpha when measured using a competitive radioligand binding assay.
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