Conversion of Aquifex aeolicus 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthase, a Metalloenzyme, into a Nonmetalloenzyme
Journal of the American Chemical Society2004Vol. 126(24), pp. 7448–7449
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Abstract
The Aquifex aeolicus 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS), a class II metalloenzyme, is converted into an active nonmetalloenzyme by a single amino acid mutation, namely, C11N. The result may provide insight into the evolutionary link between the two KDO8PS classes as well as the potential role of the metal and/or asparagine in the catalytic mechanism.
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