Poly(choloyl)-Based Amphiphiles as Pore-Forming Agents: Transport-Active Monomers by Design
Citations Over TimeTop 10% of 2005 papers
Abstract
This paper describes the design and synthesis of a family of pore-forming amphiphiles. Two of these amphiphiles, which are derived from cholic acid, lysine, and p-phenylenediamine, can produce pores in lipid bilayers as individual molecules. In sharp contrast, analogous amphiphiles that do not contain a rigid 1,4-phenylenediamide moiety favor the formation of dimer-based pores. Kinetic evidence in support of monomer- and dimer-based pores has been obtained from Na+ transport measurements across bilayers made from 1-palmitoyl-2-oleoyl-2-sn-glycero-3-phosphocholine (POPC). Structure-activity studies that have been carried out with pore-forming, dimer-based amphiphiles have also revealed a significant activity dependence on their overall compactness. The practical potential of pore-forming amphiphiles with controllable supramolecular properties is briefly discussed.
Related Papers
- → Copolymerization of monomethyl maleate and ‐fumarate with styrene(1985)7 cited
- → Alternating Copolymerization(1989)8 cited
- → Copolymerization of 2-Vinylnaphthalene with Benzyudenemalononitrile(1994)1 cited
- → Copolymerization of divinyl and monovinyl monomers(2009)
- Research progress in fluoroalkenes copolymerization(2005)