Total Synthesis of (±)-Welwitindolinone A Isonitrile
Journal of the American Chemical Society2006Vol. 128(5), pp. 1448–1449
Citations Over TimeTop 10% of 2006 papers
Abstract
A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol.
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