Palladium-Catalyzed [3 + 3] Cycloaddition of Trimethylenemethane with Azomethine Imines
Journal of the American Chemical Society2006Vol. 128(19), pp. 6330–6331
Citations Over TimeTop 10% of 2006 papers
Abstract
A palladium-catalyzed [3 + 3] cycloaddition of trimethylenemethane (TMM) with azomethine imines has been developed to produce hexahydropyridazine derivatives under simple and mild conditions. The use of substituted TMM precursors highlights the difference of this system from previously reported [3 + 2] cycloaddition of TMMs under palladium catalysis. The present [3 + 3] cycloaddition reactions are also applicable to couplings with nitrones.
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