The Catalytic Enantioselective, Protecting Group-Free Total Synthesis of (+)-Dichroanone
Journal of the American Chemical Society2006Vol. 128(24), pp. 7738–7739
Citations Over TimeTop 10% of 2006 papers
Abstract
Herein we report the first enantioselective total synthesis of (+)-dichroanone, confirming the absolute configuration of the natural product. This protecting group-free route features the first application of our enantioselective Tsuji allylation in the context of a natural product total synthesis. Additionally, this 11-step preparation of the molecule from commercial material features a novel Kumada-aromatization strategy and a rapid sequence for the conversion of a phenol to a hydroxy-p-benzoquinone.
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