Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry
Journal of the American Chemical Society2006Vol. 128(50), pp. 15972–15973
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Adam D. Moorhouse, Ana Mafalda Santos, Mekala Gunaratnam, Michael J. Moore, Stephen Neidle, John E. Moses
Abstract
A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some of these compounds also inhibit telomerase at low micromolar concentration.
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