A Protein Nanocarrier from Charge-Conversion Polymer in Response to Endosomal pH
Journal of the American Chemical Society2007Vol. 129(17), pp. 5362–5363
Citations Over TimeTop 1% of 2007 papers
Abstract
A new type of polyion complex (PIC) micelle was prepared from lysozyme and the block copolymer, PEG-pAsp(EDA-Cit), that can switch the charge from anionic to cationic at the endosomal pH. The charge-conversion was due to the degradation of the citraconic amide side chain at pH 5.5. This abrupt charge-conversion can make the PIC micelles promptly release the internal protein in response to the endosomal pH. This pH-sensitive charge-conversion polymer is promising for the future design of nanocarriers for early endosomal release.
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