A Facile One-Step in situ Functionalization of Quantum Dots with Preserved Photoluminescence for Bioconjugation
Journal of the American Chemical Society2007Vol. 129(20), pp. 6380–6381
Citations Over TimeTop 10% of 2007 papers
Qiangbin Wang, Yang Xu, Xiaohang Zhao, Yung Chang, Yan Liu, Lijing Jiang, Jaswinder Sharma, Dong‐Kyun Seo, Hao Yan
Abstract
Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core−shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.
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