Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects
Journal of the American Chemical Society2010Vol. 132(21), pp. 7260–7261
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Abstract
The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the lithiation by in situ React IR allowed the direct observation of a prelithiation complex.
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