Biomimetic Synthesis of the Antimalarial Flindersial Alkaloids
Journal of the American Chemical Society2012Vol. 134(16), pp. 6936–6939
Citations Over TimeTop 10% of 2012 papers
Abstract
A biomimetic strategy for the synthesis of the antimalarial flindersial alkaloids is described. Flinderoles A, B, and C, desmethylflinderole C, isoborreverine, and dimethylisoborreverine were all synthesized in three steps from tryptamine. The key step is an acid-promoted dimerization of the natural product borrerine. This approach is thought to mirror the biosynthesis of these compounds.
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