Concise Enantiospecific Total Synthesis of Tubingensin A
Journal of the American Chemical Society2014Vol. 136(8), pp. 3036–3039
Citations Over TimeTop 10% of 2014 papers
Abstract
We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds.
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