Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
Journal of the American Chemical Society2014Vol. 136(14), pp. 5257–5260
Citations Over TimeTop 1% of 2014 papers
Abstract
The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.
Related Papers
- → Molecular Design Based on 3D Pharmacophores. Applications to 5-HT7Receptors(2004)21 cited
- → <i>In-Silico</i> Identification of Anticancer Compounds; Ligand-Based Pharmacophore Approach against EGFR Involved in Breast Cancer(2021)6 cited
- → Applications of Pharmacophore Mapping☆(2014)3 cited
- → PHARMACOPHORE BASED SCREENING OF EPICATECHIN AGAINST COLON CANCER(2012)1 cited
- → Computational Modeling of Selective Pharmacophores at the α 1 ‐Adrenergic Receptors(2008)2 cited