Dual Native Chemical Ligation at Lysine
Journal of the American Chemical Society2009Vol. 131(38), pp. 13592–13593
Citations Over TimeTop 1% of 2009 papers
Abstract
A thiol group introduced on the gamma-carbon of lysine mediates robust native chemical ligation at both the alpha- and epsilon-amines in two consecutive steps. Desulfurization then affords the final product, in which the lysine residue at the ligation site has an isopeptide bond on its side chain. The method is useful for the synthesis of proteins containing special post-translational modifications on lysine.
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