Simplifying native chemical ligation with an N-acylsulfonamide linker
Chemical Communications2012Vol. 48(20), pp. 2579–2579
Citations Over Time
Abstract
We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.
Related Papers
- → One-pot native chemical ligation by combination of two orthogonal thioester precursors(2017)37 cited
- → A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation(2021)25 cited
- → Simplifying native chemical ligation with an N-acylsulfonamide linker(2012)16 cited
- → Side-chain assisted ligation in protein synthesis(2009)19 cited
- → A new method of N to C sequential ligation using thioacid capture ligation and native chemical ligation(2018)2 cited