Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles1
Journal of the American Chemical Society1996Vol. 118(12), pp. 2825–2842
Citations Over TimeTop 10% of 1996 papers
J. T. Link, Subharekha Raghavan, Michel Gallant, Samuel J. Danishefsky, Ting‐Chao Chou, Lawrence M. Ballas
Abstract
The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo-glycal by direct epoxidation. The second bond was assembled from an exo-glycal by intramolecular iodoglycosylation.
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