Two-Dimensional Mass Spectrometry Analysis of IgG1 Antibodies
Journal of the American Society for Mass Spectrometry2021Vol. 32(7), pp. 1716–1724
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Johanna Paris, Tomos E. Morgan, Bryan P. Marzullo, Christopher A. Wootton, Mark P. Barrow, John O’Hara, Peter B. O’Connor
Abstract
Two-dimensional mass spectrometry (2DMS) is a new, and theoretically ideal, data-independent analysis tool, which allows the characterization of a complex mixture and was used in the bottom-up analysis of IgG1 for the identification of post-translational modifications. The new peak picking algorithm allows the distinction between chimeric peaks in proteomics. In this application, the processing of 2DMS data correlates fragments to their corresponding precursors, with fragments from precursors which are m/z at m/z 840 easily resolved, without the need for quadrupole or chromatographic separation.
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