Quantitative structure-activity relationships of antitumor guanidinothiazolecarboxamides with survival enhancement for therapy in the 3LL Lewis lung carcinoma model

Citations Over Time

Abstract

Guanidinothiazolecarboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL Lewis lung carcinoma. A series of substituted benzothiazole GTCs were found to produce enhancement of survival in this model by using 8 days of intraperitoneal dosing initiated 2 days after intravenous tumor challenge. Quantitative structure-activity relationships have been discovered in the GTC series with survival enhancement correlated to substituent parameters. Optimal correlations were found between the probit transform of the drug-induced increased lifespan (ILS) and field and pi parameters. Among the most effective analogues in this series was N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxam ide.

Related Papers

• → Antitumor and Other Effects of 24<i>R</i>,25-Dihydroxycholecalciferol in Lewis Lung Carcinoma Causing Abnormal Calcium Metabolism in Tumor-Bearing Mice(1988)10 cited
• → The Antitumor Activity of Dinitrosyl Iron Complexes with Mercaptosuccinate in Murine Solid Tumor Models(2019)4 cited
• Функциональная активность фагоцитов и образование производных оксида азота в организме мышей с перевиваемыми опухолями(2011)
• Relationship between effect of tetramethylpyrazine and Danshen on inhibiting Lewis lung carcinoma growth and tumor angiogenesis(2004)
• [Effects of bimolane on size, metastases and cyclic AMP levels of Lewis lung carcinoma].(1984)