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Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus
Journal of Medicinal Chemistry1989Vol. 32(2), pp. 450–455
Citations Over TimeTop 10% of 1989 papers
Guy D. Diana, David Cutcliffe, Richard C. Oglesby, Michaël Otto, John P. Mallamo, Vahan Akullian, Mark A. McKinlay
Abstract
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (MIC) against five rhinovirus serotypes correlated well with log P. The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 microM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.
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