Organic phosphorus compounds. 5. (4-Benzothiazol-2-ylbenzyl)amidophosphonate as potent calcium antagonistic vasodilators

Citations Over Time

Abstract

Structural modifications of the calcium antagonist fostedil (KB-944) and their coronary vasodilator activity are described. Amidophosphonates 4a-m, lactam amidophosphonates 7a-1, and diamide dilactam 10 were prepared, and their coronary vasodilator activity was assessed in dogs. Many compounds exhibited coronary vasodilator activity superior to that of fostedil. Among them, the 2-oxopyrrolidine derivative 7a was the most effective compound. Its action as a coronary vasodilator was 3 and 2 times more potent than that of fostedil and diltiazem hydrochloride, respectively.

Related Papers

• → Lambert-Eaton myasthenic syndrome without anti-calcium channel antibody: adverse effect of calcium antagonist diltiazem.(1992)23 cited
• → Diltiazem, an antagonist of calcium channels, reduces norepinephrine in the rat myocardium(2006)2 cited
• → Calcium Antagonist Effect on Adhesion Formation(1989)1 cited
• → Preventive Effect on Stroke of a Calcium Antagonist and Its Mechanisms in SHR(1984)1 cited
• → 02 The Ca2+ channel antagonist diltiazem blocks glibenclamide-induced malignant arrhythmias during reperfusion in sheep(2002)