Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics
Journal of Medicinal Chemistry2002Vol. 45(17), pp. 3576–3578
Citations Over TimeTop 17% of 2002 papers
Kevin J. Duffy, Alan T. Price, Evelyne Delorme, Susan B. Dillon, Céline Duquenne, Connie L. Erickson‐Miller, Leslie Giampa, Yifang Huang, Richard M. Keenan, Peter Lamb, Nannan Liu, Stephen G. Miller, Jon Rosen, Anthony N. Shaw, Heather Smith, Kenneth J. Wiggall, Lihua Zhang, Juan I. Luengo
Abstract
The invention of a new class of naphtho[1,2-d]imidazole thrombopoietin mimics based on a pharmacophore hypothesis for small-molecule thrombopoietic agonists is discussed. Parallel array synthesis and purification techniques allowed for the rapid exploration of structure-activity relationships within this class and for the improvement in TPO mimetic potencies and efficacies.
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