Identification of 2-{2-[2-(5-Bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole (ML00253764), a Small Molecule Melanocortin 4 Receptor Antagonist That Effectively Reduces Tumor-Induced Weight Loss in a Mouse Model
Journal of Medicinal Chemistry2004Vol. 47(7), pp. 1602–1604
Citations Over TimeTop 10% of 2004 papers
Tricia J. Vos, Andrei Caracoti, L. McGlothan Jennifer, Mingshi Dai, Cheryl A. Farrer, Nancy E. Forsyth, Stacey Drabic, Robert A. Horlick, Diana Lamppu, David Yowe, Suresh K. Balani, Ping Li, Hang Zeng, Ingrid B.J. Joseph, Luis E. Rodrı́guez, Martin P. Maguire, Michael A. Patane, Christopher F. Claiborne
Abstract
The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body weight and/or food intake in several rodent models. We report here the identification of a novel nonpeptidic MC4R antagonist and its effects on tumor-induced weight loss in mice following peripheral administration.
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