Entry into a New Class of Potent Proteasome Inhibitors Having High Antiproliferative Activity by Structure-Based Design
Journal of Medicinal Chemistry2004Vol. 47(20), pp. 4810–4813
Citations Over TimeTop 21% of 2004 papers
Pascal Furet, Patricia Imbach, Maria Noorani, Juergen Koeppler, Kurt Laumen, Marc Lang, Vito Guagnano, Peter G. Fuerst, Johannes Roesel, Johann Zimmermann, Carlos Garcı́a-Echeverrı́a
Abstract
Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.
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