A Positron Emission Tomography Radioligand for the in Vivo Labeling of Metabotropic Glutamate 1 Receptor: (3-Ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone
Journal of Medicinal Chemistry2005Vol. 48(16), pp. 5096–5099
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Yiyun Huang, Raj Narendran, François Bischoff, Ningning Guo, Zhihong Zhu, Sung‐A Bae, Anne Lesage, Marc Laruelle
Abstract
A selective metabotropic glutamate 1 receptor (mGlu1) antagonist was labeled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studies and micro-positron emission tomography (micro-PET) imaging experiments in rats. Results from animal experiments demonstrate that the radioligand [11C]2 is the first PET tracer capable of labeling the rat mGlu1 receptor in vivo.
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