4-Aminothiazolyl Analogues of GE2270 A: Antibacterial Lead Finding
Journal of Medicinal Chemistry2011Vol. 54(7), pp. 2517–2521
Citations Over TimeTop 16% of 2011 papers
Matthew J. LaMarche, Jennifer A. Leeds, Joanne Dzink-Fox, Karl Gunderson, Philipp Krastel, Klaus Memmert, Michael A. Patane, Elin M. Rann, E. Schmitt, Stacey Tiamfook, Bing Wang
Abstract
4-Aminothiazolyl analogues of the antibacterial natural product GE2270 A (1) were designed, synthesized, and evaluated for gram positive bacteria growth inhibition. The aminothiazole-based chemical template was evaluated for chemical stability, and its decomposition revealed a novel, structurally simplified, des-thiazole analogue of 1. Subsequent stabilization of the 4-aminothiazolyl functional motif was achieved and initial structure activity relationships defined.
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