Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTThrough the "Gatekeeper Door": Exploiting the Active Kinase ConformationFabio Zuccotto*†, Elena Ardini‡, Elena Casale†, and Mauro Angiolini§View Author Information† Department of Chemical Core Technologies‡ Department of Cell Biology Signal Transduction§ Department of Medicinal Chemistry Nerviano Medical Sciences, Oncology, Viale Pasteur 10, Nerviano 20014, Italy*To whom correspondence should be addressed. Phone: +39-0331-581103. Fax: +39-0331-581106. E-mail: [email protected]Cite this: J. Med. Chem. 2010, 53, 7, 2681–2694Publication Date (Web):December 14, 2009Publication History Received29 September 2009Published online14 December 2009Published inissue 8 April 2010https://pubs.acs.org/doi/10.1021/jm901443hhttps://doi.org/10.1021/jm901443hreview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views15387Altmetric-Citations412LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cavities,Inhibitors,Kinase inhibitors,Peptides and proteins,Pharmacophores Get e-Alerts

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

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