Conformationally Constrained 1,3-Diamino Ketones: A Series of Potent Inhibitors of the Cysteine Protease Cathepsin K
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Abstract
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTConformationally Constrained 1,3-Diamino Ketones: A Series of Potent Inhibitors of the Cysteine Protease Cathepsin KRobert W. Marquis, Dennis S. Yamashita, Yu Ru, Stephen M. LoCastro, Hye-Ja Oh, Karl F. Erhard, Renee L. DesJarlais, Martha S. Head, Ward W. Smith, Baoguang Zhao, Cheryl A. Janson, Sherin S. Abdel-Meguid, Thaddeus A. Tomaszek, Mark A. Levy, and Daniel F. VeberView Author Information Departments of Medicinal Chemistry, Structural and Physical Chemistry, Structural Biology, and Molecular Recognition, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406 Cite this: J. Med. Chem. 1998, 41, 19, 3563–3567Publication Date (Web):August 19, 1998Publication History Received11 May 1998Published online19 August 1998Published inissue 1 September 1998https://doi.org/10.1021/jm980295fCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views754Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (191 KB) Get e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Anatomy,Inhibitors,Ketones,Molecular structure,Peptides and proteins Get e-Alerts
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