Structure−Activity Relationship Studies of Illudins: Analogues Possessing a Spiro-cyclobutane Ring
The Journal of Organic Chemistry2003Vol. 68(25), pp. 9648–9653
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Abstract
Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.
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