Pseudoprolines as Removable Turn Inducers: Tools for the Cyclization of Small Peptides
The Journal of Organic Chemistry2004Vol. 69(25), pp. 8804–8809
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Abstract
The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.
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