A Soluble Base for the Copper-Catalyzed Imidazole N-Arylations with Aryl Halides
The Journal of Organic Chemistry2005Vol. 70(24), pp. 10135–10138
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Abstract
[reaction: see text] CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base, 8-hydroxyquinoline as ligand, and H2O as cosolvent. Preliminary results with aryl chlorides are also reported.