Biomimetic Semisynthesis of Arglabin from Parthenolide
The Journal of Organic Chemistry2012Vol. 77(16), pp. 7103–7107
Citations Over TimeTop 15% of 2012 papers
Jiadai Zhai, Dongmei Li, Jing Long, Haoliang Zhang, Jianping Lin, Chuanjiang Qiu, Quan Zhang, Yue Chen
Abstract
The semisynthesis of arglabin, an anticancer drug in clinical application, is developed from abundant natural product parthenolide via three steps. Each step in this sequence is highly stereoselective, and the substrate-dependent stereoselectivity in the epoxidation step can be explained by computational calculations. The success of chemical semisynthesis of arglabin suggests that the biosynthesis of arglabin might proceed in a similar pathway.
Related Papers
- → Biomimetic Semisynthesis of Arglabin from Parthenolide(2012)76 cited
- → Biosynthetic medicinal chemistry of natural product drugs(2012)45 cited
- → Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine(2019)45 cited
- → Emerging concepts in the semisynthetic and mutasynthetic production of natural products(2022)16 cited
- → Synthesis and biological properties of macrolactam analogs of the natural product macrolide (−)-A26771B(2011)22 cited