One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles
The Journal of Organic Chemistry2013Vol. 78(11), pp. 5800–5803
Citations Over TimeTop 25% of 2013 papers
Rogelio P. Frutos, Xudong Wei, Nitinchandra D. Patel, Thomas G. Tampone, Jason A. Mulder, Carl A. Busacca, Chris H. Senanayake
Abstract
A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.
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