Rogelio P. Frutos
Boehringer Ingelheim (United States)(US)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Asymmetric Synthesis and Catalysis, Click Chemistry and Applications, Cell Adhesion Molecules Research, Synthetic Organic Chemistry Methods
Most-Cited Works
- → Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis(2006)159 cited
- → Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions(1994)45 cited
- → Development of a Safe and Economical Synthesis of Methyl 6-Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale(2013)31 cited
- → An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template(2001)30 cited
- → One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles(2013)30 cited
- → Synthesis of protected, chiral α,α-disubstituted α-amino acids via a Beckmann rearrangement(1998)26 cited
- → Expedient synthesis of substituted imidazoles from nitriles(2005)25 cited
- → Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters(2003)23 cited
- → A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins(2004)22 cited
- → Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation(2018)21 cited