A Palladium-Catalyzed Alkylation/Direct Arylation Synthesis of Nitrogen-Containing Heterocycles
The Journal of Organic Chemistry2008Vol. 73(5), pp. 1888–1897
Citations Over TimeTop 10% of 2008 papers
Christophe Blaszykowski, Evangelos Aktoudianakis, Dino Alberico, Cyril Bressy, David G. Hulcoop, Farnaz Jafarpour, Arash Joushaghani, Benoı̂t Laleu, Mark Lautens
Abstract
A norbornene-mediated palladium-catalyzed sequence is described in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one reaction vessel. The aryl-heteroaryl bond-forming step occurs via a direct arylation reaction. A number of six-, seven-, and eight-membered ring-annulated indoles, pyrroles, pyrazoles, and azaindoles were synthesized from the corresponding bromoalkyl azole and an aryl iodide.
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