A Practical and Efficient Route for the Highly Enantioselective Synthesis of Mexiletine Analogues and Novel β-Thiophenoxy and Pyridyl Ethers
The Journal of Organic Chemistry2008Vol. 73(17), pp. 6928–6931
Citations Over TimeTop 12% of 2008 papers
Abstract
A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel beta-amino ethers containing thiophenyl and pyridyl fragments.
Related Papers
- → Organocatalysis in Radical Chemistry. Enantioselective α-Oxyamination of Aldehydes(2007)294 cited
- → Enantioselective synthesis of dihydroquinazolinone derivatives catalyzed by a chiral organocatalyst(2017)20 cited
- → Synthesis of Perfluoroalkyl‐Substituted Bis(oxazolines) as Ligands for Catalytic Enantioselective Reactions.(2003)
- → Modified BINAPO Ligands for Rh‐Catalyzed Enantioselective Hydrogenation of Acetamidoacrylic Acids and Esters.(2003)
- → ChemInform Abstract: Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines(2012)