Batzelladines F−I, Novel Alkaloids from the Sponge Batzella sp.: Inducers of p56lck-CD4 Dissociation
The Journal of Organic Chemistry1997Vol. 62(6), pp. 1814–1819
Citations Over TimeTop 10% of 1997 papers
Ashok D. Patil, Alan J. Freyer, Paul B. Taylor, Brad Carté, Gary E. Zuber, Randall K. Johnson, D. John Faulkner
Abstract
The sponge Batzella sp. from Jamaica contains four new alkaloids, batzelladines F−I (1-4), that induce the p56lck−CD4 dissociation. Batzelladines F−I were isolated using a bioassay-directed fractionation scheme and were identified by interpretation of spectroscopic data. Batzelladines F, G, and H + I were active in the p56lck−CD4 dissociation assay at micromolar concentrations.
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