Enhancement of Neurite Outgrowth in Neuronal-Like Cells following Boron Nitride Nanotube-Mediated Stimulation
ACS Nano2010Vol. 4(10), pp. 6267–6277
Citations Over TimeTop 10% of 2010 papers
Gianni Ciofani, Serena Danti, Delfo D’Alessandro, Leonardo Ricotti, Stefania Moscato, Giovanni Bertoni, Andrea Falqui, Stefano Berrettini, Mario Petrini, Virgilio Mattoli, Arianna Menciassi
Abstract
In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.
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