A New Dimeric Dihydrochalcone and a New Prenylated Flavone from the Bud Covers ofArtocarpusaltilis: Potent Inhibitors of Cathepsin K
Journal of Natural Products2002Vol. 65(4), pp. 624–627
Citations Over TimeTop 25% of 2002 papers
Ashok D. Patil, Alan J. Freyer, Lew Killmer, Priscilla Offen, Paul B. Taylor, Bartholomew J. Votta, Randall K. Johnson
Abstract
A MeOH/CH(2)Cl(2) extract of the bud covers of Artocarpus altilis collected in Micronesia showed activity in a cathepsin K inhibition assay. In addition to the three known flavonoids isolated from the bud covers of this species, two new compounds have been identified whose structures were determined on the basis of spectral data. These compounds include a dimeric dihydrochalcone, cycloaltilisin 6 (2), and a new prenylated flavone, cycloaltilisin 7 (3). Novel compounds 2 and 3 have IC(50) values of 98 and 840 nM, respectively, in cathepsin inhibition.
Related Papers
- → Wood phenolics in the chemotaxonomy of the moraceae(1972)97 cited
- → Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs(2004)74 cited
- → Preliminary phytochemical analysis of Ficus johanis Subsp. afghanistanica from Moraceae family(2022)
- → ХИМИЧЕСКИЙ СОСТАВ И ПРИМЕНЕНИЕ В МЕДИЦИНЕ РАСТЕНИЙ, ПРИНАДЛЕЖАЩИХ К СЕМЕЙСТВУ MORUS РОДА MORACEAE(2023)
- → ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ(2024)