Mirabamides E−H, HIV-Inhibitory Depsipeptides from the Sponge Stelletta clavosa
Journal of Natural Products2011Vol. 74(2), pp. 185–193
Citations Over TimeTop 10% of 2011 papers
Zhenyu Lu, Ryan M. Van Wagoner, Mary Kay Harper, Heather L. Baker, John N. A. Hooper, Carole A. Bewley, Chris M. Ireland
Abstract
Four new depsipeptides, mirabamides E-H (1-4), and the known depsipeptide mirabamide C (5) have been isolated from the sponge Stelletta clavosa, collected from the Torres Strait. The planar structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The absolute configurations were established by the advanced Marfey's method, NMR, and GC-MS. The four new compounds all showed strong inhibition of HIV-1 in a neutralization assay with IC(50) values of 121, 62, 68, and 41 nM, respectively.
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