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Conioidines A and B, Novel DNA-interacting Pyrrolidines from Chamaesaracha conioides
Journal of Natural Products1993Vol. 56(5), pp. 708–713
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George W. Chan, David E. Berry, Charles DeBrosse, Mark E. Houling, Laurie MacKenzie-LoCasto, Priscilla Offen, John Westley
Abstract
Two novel pyrrolidine compounds, conioidines A [1] and B [2], have been isolated from the Texas plant, Chamaesaracha conioides (Solanaceae). Their structures were determined by spectroscopic methods and hydrolysis studies. Both natural products, like doxorubicin, showed DNA-specific KB cell cytotoxicity. Dose-response data indicated a Kd value of 2.8 microM for binding of conioidine A [1] to calf thymus DNA.
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