0 citations
Antimitotic and Cytotoxic Flavonols from Zieridium pseudobtusifolium and Acronychia porteri
Journal of Natural Products1994Vol. 57(7), pp. 1012–1016
Citations Over TimeTop 14% of 1994 papers
J. Lichius, Odile Thoison, Alain Montagnac, Mary Paı̈s, Françoise Guéritte-Voegelein, Thierry Sévenet, Jean‐Pierre Cosson, A. Hamid A. Hadi
Abstract
Bioassay-guided fractionation of the extracts of Zieridium pseudobtusifolium and Acronychia porteri led to the isolation of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone [1], which showed activity against (KB) human nasopharyngeal carcinoma cells (IC50 0.04 micrograms/ml) and inhibited tubulin assembly into microtubules (IC50 12 microM). Two other known flavonols, digicitrin [2] and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone [5], were also isolated together with three new ones, 3-O-demethyldigicitrin [3], 3,5,3'-trihydroxy-6,7,8,4'-tetramethoxyflavone [4], and 3,5-dihydroxy-6,7,8,3',4'-pentamethoxyflavone [6]. All of these flavonols showed cytotoxic activity against KB cells.
Related Papers
- → Flavonols and flavones in food plants: a review(1976)579 cited
- → Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability(2000)168 cited
- → The UVA and Aqueous Stability of Flavonoids Is Dependent on B-Ring Substitution(2012)64 cited
- → A Protocol for Flavonols, Kaempferol and Quercetin, Staining in Plant Root Tips(2020)7 cited
- → Amount of flavonols and stilbenes during needle development of Picea abies; variations between provenances(1998)24 cited