Synthesis of Tri- and Tetrasubstituted Furans Catalyzed by Trifluoroacetic Acid
Organic Letters2000Vol. 2(23), pp. 3535–3537
Citations Over TimeTop 21% of 2000 papers
Abstract
Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an α-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans.
Related Papers
- → Synthesis of Tri- and Tetrasubstituted Furans Catalyzed by Trifluoroacetic Acid(2000)62 cited
- → Trifluoroacetic acid prompted unexpected visible to NIR switching of ketoenamine-substituted triphenylamines(2023)7 cited
- → Aziridination of alkenes using 3-amino-2-ethylquinazolin-4(3H)-one and lead tetra-acetate–trifluoroacetic acid(1989)13 cited
- The Synthesis and Application of Trifluoroacetic Acid(2014)