Enzyme-Catalyzed Asymmetric Deacylation for the Preparation of Lasofoxifene (CP-336156), a Selective Estrogen Receptor Modulator
Organic Letters2000Vol. 2(25), pp. 4025–4027
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Abstract
[structure] selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from the chiral centers.
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