A Concise, Selective Synthesis of the Polyketide Spacer Domain of a Potent Bryostatin Analogue
Organic Letters2003Vol. 5(3), pp. 277–279
Citations Over TimeTop 19% of 2003 papers
Abstract
[reaction: see text] A concise, asymmetric synthesis of the polyketide spacer domain portion (C1-C13) of a highly potent bryostatin analogue was developed. The route utilizes asymmetric hydrogenation methodology to install the C3, C5, and C11 stereocenters, while a substrate directed syn reduction sets the C9 stereocenter. The spacer domain 1 is obtained in 10 steps with a 25% overall yield and is readily incorporated into the synthesis of 2.
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