Cobalt-Catalyzed Cycloisomerization of 1,6-Enynes and Allyl Propargyl Ethers
Organic Letters2003Vol. 5(14), pp. 2409–2411
Citations Over TimeTop 14% of 2003 papers
Abstract
[reaction: see text] 1,6-Enynes and allyl propargyl ethers undergo a cobalt-catalyzed formal 5-endo-dig cyclization to form vinyl cyclopentenes and dihydrofurans, respectively. The use of equimolar amounts of dicobalt octacarbonyl and trimethyl phosphite affords optimum yields and improved selectivity for cycloisomerization vs alkene isomerization.
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