Efficient Synthesis of Substituted Vinyl Ethers Using the Julia Olefination
Organic Letters2003Vol. 5(25), pp. 4851–4854
Citations Over TimeTop 14% of 2003 papers
Abstract
Julia olefination between alpha-alkoxy sulfones 2a-c and a wide variety of ketones or aldehydes afforded substituted vinyl ethers in 46-90% yields. Sulfones 2a-c were readily prepared in two steps from commercially available reagents in 68-80% yields. Optimization revealed that the nature of the base, the solvent, and the temperature were crucial to obtaining the desired vinyl ethers. [reaction: see text]
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