Novel One-Pot Total Syntheses of Deoxyvasicinone, Mackinazolinone, Isaindigotone, and Their Derivatives Promoted by Microwave Irradiation
Organic Letters2005Vol. 7(15), pp. 3363–3366
Citations Over TimeTop 10% of 2005 papers
Jifeng Liu, Ye Ping, Kevin Sprague, Katie Sargent, Daniel Yohannes, Carmen M. Baldino, Christopher J. Wilson, Shi‐Chung Ng
Abstract
[reaction: see text]. Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.
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